Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis.
نویسندگان
چکیده
The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels.
منابع مشابه
Efficacy of aerosolized amphotericin B desoxycholate and liposomal amphotericin B in the treatment of invasive pulmonary aspergillosis in severely immunocompromised rats.
The effects of treatment with aerosolized amphotericin B desoxycholate and aerosolized liposomal amphotericin B were evaluated in severely immunosuppressed rats with invasive pulmonary aspergillosis. Aerosol treatment with amphotericin B desoxycholate consisted of a single dose (60 min) with amphotericin B concentrations in the nebulizer reservoir of 1, 2 and 4 mg/mL, respectively. For liposoma...
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bronchopulmonary aspergillosis. Ann Allergy Asthma Immunol 1999; 82: 511–516. 4 Salez F, Brichet A, Desurmont S, et al. Effect of itraconazole therapy in allergic bronchopulmonary aspergillosis. Chest 1999; 116: 1665–1668. 5 Montoya JG, Chaparro SV, Celis D, et al. Invasive aspergillosis in the setting of cardiac transplantation. Clin Infect Dis 2003; 37: 281–292. 6 Rijnders BJ, Cornelissen JJ,...
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Targeted intrapulmonary delivery of drugs may reduce systemic toxicity and improve treatment efficacy. In the current study, we evaluated the effects of a combination treatment consisting of inhalation of aerosolized liposomal amphotericin B (L-AMB) with intraperitoneal administration of micafungin (MCFG) against murine invasive pulmonary aspergillosis. The combination of aerosolized L-AMB with...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 49 7 شماره
صفحات -
تاریخ انتشار 2005